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Archive for March, 2008

Naglazyme Approved by Japanese Ministry of Health

Monday, March 31st, 2008

BioMarin Pharmaceutical Inc. (Nasdaq and SWX: BMRN) announced today that AnGes MG, Inc. (AnGes), BioMarin’s marketing and distribution partner in Japan, has received approval for its Marketing Application for Naglazyme(R) (galsulfase) from the Japanese Ministry of Health, Labour and Welfare (MHLW) for the treatment of patients with Mucopolysaccharidosis VI ( MPS VI).(original article)

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Epilepsy advocates propose strategies to heighten treatment expectations

Monday, March 31st, 2008

On the heels of the nation’s largest event dedicated to the epilepsy community, the National Walk for Epilepsy, advocates today announced their recommendations in response to a new national survey uncovering key challenges facing the epilepsy community.(original article)

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Potential new target for multiple sclerosis therapy

Monday, March 31st, 2008

Researchers demonstrate both genetic and pharmaceutical evidence for the role of a protein called collagenase-2 in the development of multiple sclerosis (MS), providing a potential new way to combat this debilitating disease.(original article)

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Study validates Pittsburgh Compound-B in identifying Alzheimer's disease brain toxins

Friday, March 28th, 2008

A groundbreaking study conducted by University of Pittsburgh Alzheimer’s disease researchers reported in the journal Brain (currently online) confirms that Pittsburgh Compound-B (PiB) binds to the telltale beta-amyloid deposits found in the brains of patients with Alzheimer’s disease.(original article)

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FDA deadlines may compromise drug safety by rushing approval

Friday, March 28th, 2008

Many medications are approved by the U.S. Food and Drug Administration on the brink of congressionally mandated deadlines, and those drugs are more likely to face later regulatory intervention than those approved with greater deliberation, researchers at Harvard University have found.(original article)

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Anticancer siRNA therapy advances, thanks to nanoparticles

Thursday, March 27th, 2008

Small pieces of nucleic acid, known as siRNAs (short interfering RNAs), can turn off the production of specific proteins, a property that makes them one of the more promising new classes of anticancer drugs in development. Indeed, at least two siRNA-based anticancer therapies, both delivered to tumors in nanoparticles, have begun human clinical trials. Now, three new reports highlight the progress that researchers are making in developing broadly applicable, nanoparticle-enabled siRNA anticancer therapeutics.(original article)

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Study shows use of asthma medication contradicts guidelines

Thursday, March 27th, 2008

A study has found only 16 per cent of the 352,082 Australians who filled a prescription for asthma preventer medications for the first time during the period July 2004 to June 2005, went on to use them regularly.(original article)

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Heart Failure Treated 'In The Brain'

Wednesday, March 26th, 2008

Beta-blockers heal the heart via the brain when administered during heart failure, according to a new study by UCL (University College London). Up to now, it was thought that beta-blockers work directly on the heart, but the new study shows that the drugs may also act via the brain, suggesting that future therapies to treat cardiovascular disease could be targeting the central nervous system.Heart failure patients are routinely given beta-blockers, although doctors do not know exactly how these drugs boost cardiac performance and reduce the risk of death. The UCL study, based on the rat model of postmyocardial infarction-induced heart failure and published in the journal Circulation Research, has discovered that the beta-adrenoceptor blocker metoprolol acts directly in the brain to slow the progression of heart failure. The action seems to be localised to a group of brain cells that UCL researchers have identified previously as being crucial in the control of blood pressure and heart rate.

(more…)

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Food Prices Soaring Worldwide

Tuesday, March 25th, 2008

Food prices soaring worldwide

By KATHERINE CORCORAN, Associated Press Staff Writer 1 hour, 39 minutes ago

MEXICO CITY - If you’re seeing your grocery bill go up, you’re not alone.

From subsistence farmers eating rice in Ecuador to gourmets feasting on escargot in France, consumers worldwide face rising food prices in what analysts call a perfect storm of […](original article)

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The focus on HIV/AIDS has helped forget the threat of tuberculosis

Monday, March 24th, 2008

A leading Australian expert has warned that the international attention devoted to HIV/AIDS has dwarfed the threat of tuberculosis (TB).(original article)

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Too much information? Study shows how ignorance can be influential

Monday, March 24th, 2008

In the current issue of The RAND Journal of Economics, USC researchers provide a challenge to the classic economic model of information manipulation, in which knowing more than anybody else is the key to influence.(original article)

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OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia

Monday, March 24th, 2008

Oregon Health & Science University Cancer Institute researchers have found that an experimental drug known as SGX393 is effective against Gleevec-resistant chronic myeloid leukemia (CML).(original article)

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Free drug samples may burden patients’ pockets

Monday, March 24th, 2008

Following free drug sample receipt, patients who receive these samples have significantly higher out-of-pocket prescription costs than those who don’t, according to the first study to look at the out-of-pocket cost associated with free-sample use, published in the March 24, 2008, issue of Medical Care.(original article)

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Stanford Researchers Unmask Proteins in Telomerase, a Substance That Enables Cancer

Sunday, March 23rd, 2008

One of the more intriguing workhorses of the cell, a protein conglomerate called telomerase, has in its short history been implicated in some critical areas of medicine including cancer, aging and keeping stem cells healthy.(original article)

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PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia

Sunday, March 23rd, 2008

PharmAthene, Inc., a biodefense company specializing in the development and commercialization of medical countermeasures against biological and chemical threats, and Avecia Biologics Limited, a contract manufacturer of biopharmaceuticals, announced today that the companies have entered into a definitive sale and purchase agreement under which PharmAthene will acquire all of the assets and intellectual property related to Avecia’s biodefense vaccines business.(original article)

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